Buku Ajar Fisiologi Kedokteran Ganong Pdf Editor

Might again act to regulate the biology of these critical cells. Finally, we review the role of ROS in stem cells and how oxidants Senescence by acting as important intracellular mediators. We also discuss how ROS might be involved in the induction of cellular ROS also might be involved in certain signaling events. How these observations are currently being extended to the production of ROS emanating from the mitochondria, and how mitochondrial Here, we review these observations and discuss the role of ROS in normal growth factor signaling. SubsequentĮxperiments have defined the enzymatic source of ligand activated ROS production and some of the relevant molecular targets. That after ligand addition, the subsequent production of ROS was a necessary component of downstream signaling. In this context, several groups were able to show Using cultured cells stimulated by a variety of peptide growth factors. These observations came from studies initially Realization that oxidants also can play a normal, physiological role within cells. Keywords: hypoxia, ROS, antioxidant, glutathione, liverĪlthough the pathophysiological role of reactive oxygen species (ROS) has received considerable attention, there is a growing It can be concluded that chronic systemic hypoxia causes an increase of GSH levels in liver and blood of rats. Statistical analysis showed a strong correlation (Pearson r = 0.9917) between GSH levels in liver and blood. The results of this research showed a significant increase in the levels of GSH in the liver and blood which is in line with the duration of hypoxia (p<0,05) compared with the control group. The levels of GSH in the liver and blood is examined by using the Ellman Method. Hypoxic condition is obtained by putting the rats into the hypoxia chamber (O2 8%).

The rats were divided into 7 groups (n=4/group): the control group (normoxia) and the hypoxia group 1 3 6 12 24 and 72 hours. This research aims to determine the effect of hypoxia on levels of GSH in the liver and blood of rat. Severe hypoxia causes a reduction of ATP production in the liver that plays a role in the onset of liver damage. The liver is the central of our metabolism, to be able to functionate properly it depends on the availability of oxygen. Glutathione (GSH) is an antioxidant that can bind ROS in order to prevent oxidative stress. If ROS produced exceeds the amount of the antioxidants, it will cause oxidative stress to occurs which resulted in cell injury and even leading to cell death. ROS (Reactive Oxygen Species) and antioxidants. HypoxiaHypoxia is a condition caused by lack of oxygen in the tissue, which resulting in an imbalance between pro-oxidants i.e.

Buku Ajar Fisiologi Kedokteran Ganong Pdf Editor